China Supply 9% Purity AZD 3759 CAS: 1626387-80-1 for Cancer Treatment

Item No.: 1626387-80-1
Model NO.: 1626387-80-1
Customized: Non-Customized
Suitable for: Elderly, Adult
Purity: >99%
Delivery Time: 4-7 Days
Transport Package: Foil Bag or Tin. &Well Disguised Package with Fast
Certification: GMP, ISO 9001
Appearance: White or off-White C
$0.00
INQUIRY
Description
FAQ
Quick Details:

English name: AZD 3759
English Synonyms: AZD 3759; AZD3759; AZD-3759; (2R) -2,4-Dimethyl- 1-piperazinecarboxylic acid 4 - [(3-chloro-2- fluorophenyl) amino] HY-18750; azd3579;
CAS number: 1626387-80-1
Molecular formula: C22H23ClFN5O3
Molecular weight: 459.91

Description

AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del, . AZD3759 inhibits EGFR phosphorylation with IC50 of 7.2 nM. AZD3759 showed an inhibitory effect on the proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and the EGFR mutant with IC50 of 7.7 nM and 7 nM, respectively, with no activity on the proliferation of H838 cells.
Phase 1 clinical trials of AZD3759 showed very good control activity of intracranial lesions, and the dose of this drug is recommended to be 200 mg or 300 mg twice daily. AZD3759 has no better control of extracranial lesions than the other EGFR-targeted agents, but shows greater control over intracranial lesions.

Application:

1.Non-small cell lung cancer is one of the major diseases that threaten human health. Even more serious is up to 50% of cancer patients with central nervous system metastasis in their lifetime, metastatic lung cancer is currently no cure. Recently, AstraZeneca's Chinese team led by Dr. Zhang Xiaolin successfully developed a new drug, AZD3759, to treat central nervous system metastases of lung cancer. Their early R & D results have been published in "Journal of Medicinal Chemistry".

2.In order to solve the challenging problem of blood-brain barrier, the author comprehensively optimizes structural parameters such as molecular size, polarity, rigidity and the like, and adjusts various biophysical and chemical properties such as basicity, water solubility, permeability and stability To the best condition to cross the blood-brain barrier. The fully optimized design has successfully brought AZD3759 to the same effective concentrations in different settings of the blood and central nervous system. In addition, the authors also published a preclinical in vitro and in vivo assessment of a subset of candidate compounds. Clinical studies of AZD3759 are underway.


How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .


Payment and Shipping:

Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate


Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!
 
Review

Related products