99.6% High Purity Lapatinib Ditosylate (CAS 388082-78-8)

Item No.: 388082-78-8
Model NO.:388082-78-8
Customized:Regular Commercial Lots
Certification:ISO 9001, USP, BP
Suitable for:Adult
Purity:>98%
Function:Anticancer
HS Code: 42356122
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Product Name: Lapatinib ditosylate
Synonyms:  Lapatinib ditosylate;benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate;N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate);Lapatinib Ditosilate;Lapatinib, Tykerb, GW572016;Lapatinib Ditosylate (GW-572016);lapatinib(GW572016);Lapatinib ditosylate hydrate
CAS: 388082-78-8
MF:  C41H40ClFN4O11S3
MW:  925.46
Product Categories: anti-neoplastic;Lapatinib;Anti-cancer&immunity;Inhibitors
Mol File:  388082-78-8.mol

COA:

 
TEST ITEMS SPECIFICATION RESULTS
Description Light yellow or almost white crystalline powder Light  Yellow powder
Identification IR Positive
Assay 97.0~103.0% 99.37%
Melting Point 70~80°C 70.5~76.5°C
Specific Rotation +22~+26° +23.09°
Loss On Drying 0.5%max 0.25%
Residue On Ignition 0.1%max 0.05%
Heavy Metals 20PPm max <20PPm
Organic Volatile Impurities Meets the requirement. Conforms

Related Substances
Single Impurity: 1.0%max <1.0%
Total Impurities: 2.0%max <2.0%
Conclusion The specification conforms to enterprise standard.

 
Breast Cancer:

In combination with letrozole for treatment of hormone receptor-positive metastatic breast cancer that overexpresses the human epidermal receptor type 2 (HER2) protein in postmenopausal women who are candidates for hormonal therapy.1 5 8 Combined therapy with lapatinib and an aromatase inhibitor has not been compared with trastuzumab-containing chemotherapy for treatment of metastatic breast cancer.


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