Pharmaceutical Raw Materials

Good Quality High Purity Raw Material Antimalarial Powder Artemisinin CAS 63968-64-9

Item No.: 63968-64-9
Model NO.: 63968-64-9
Customized: Customized
Suitable for: Elderly, Adult
Purity: >99%
Express: TNT, FedEx, EMS, DHL.etc
Export Markets: Global
Specification: GMP, USP
Certification: GMP, ISO 9001, USP
State: Solid
Delivery Time: 4-7 Working Days
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Description
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Quick Details:

Other names: Qinghaosu, Arteannuin, Artemisinine
Botanical Source: Artemisia Annua L. 
CAS No.: 63968-64-9
Plant Part Used: Leaf
Appearance: White needle crystal
Molecular Formula: C15H22O5
Molecular Weight: 282.33
Specification: Artemisinin 99% by HPLC

Artemisinin is Chinese first successfully developed by scientists, is the effective monomer separated from the treatment of malaria in China folk herbs of Artemisia annua, one of the major countries of the China raw materials of plant growth, development demand originated in 60s in Vietnam, has been on the chlorine Kui Plasmodium specific drug resistance, then not many soldiers died in the war, but died of malaria.

COA:

Analysis Items Specifications Results Methods used
Identification Positive Conforms Chemical method/TLC/IR
Appearance Colorless Crystal powder Conforms Visual test
Artemisinin, identification by IR Corresponds qualitatively to the
Spectrum
Corresponds qualitatively to the comparison Conforms /
Odor Characteristic pleasant Conforms Organoleptic
Taste Characteristic bitter Conforms Organoleptic
Assay on dry base Artemisinin 99% min 99.64% By HPLC
Related substance No more than 2.0% in each case Conforms HPLC
Total related substance NMT 5.0% Conforms HPLC
Melting Point 150-153ºC 152.3-152.8ºC CP2005
Clarity to the solution 1 %( m/v) Clear to slightly opalescent Clear /
Optical Rotation +75°-- +78° +75.8° Optical Rotator
Moisture Content (5g) NMT 0.5% 0.19% 1g / 80ºC
Residue on Ignition (2g) NMT 0.1% 0.03% 1g/600-750ºC
Microbiological Data Total Plate Count<1,000cfu/g < 100 cfu/g GB 4789.2
Total Yeast & Mold<100cfu/g < 30 cfu/g GB 4789.15
E. Coli to be absent /g Absent GB 4789.3
Staphylococcus to be absent/g Absent GB 4789.10
Salmonella to be absent/g Absent GB 4789.4


Application:

Artemisia used as antimalarial drugs, clinical application proves that artemisinin and its derivatives on the effects between malaria and falciparum malaria, especially arteannuin (Artemtherin), which reduced cell clones of Plasmodium is stronger than other artemisinin drugs to kill. The utility model has the advantages of high efficiency, quick acting, low toxicity and no cross resistance with chloroquine, and can be used not only for treatment, but also for emergency treatment. 

Applicable to all kinds of malaria, such as falciparum malaria, vivax malaria, chloroquine resistant malaria and cerebral malaria. Dangerous type. Most notably, dihydroartemisinin and its tablets. The efficacy of this medicine was 10 times higher than that of artemisinin, and the recurrence rate was only 1.95%. Therefore, it was named China's ten largest scientific and technological achievement in 1992. Artemisinin and its derivatives are not only an excellent antimalarial drug, but also potentially attractive in the treatment of other diseases. 

The animal experiments showed that artemisinin in the treatment of Clonorchis sinensis, killing rate reached 100%; the treatment of animal schistosomiasis, pest control rate of 33.8-99.3%. The total effective rate of artemisinin in the treatment of disk lupus erythematosus is 90%. The curative effect of the treatment of dengue fever is obviously superior to that of morpholine, guanidine and other Western medicines. The study also showed that artemisinin can significantly improve lymphocyte conversion and enhance the immune function of antibodies. No product was found to have toxic effects on heart, liver and kidney. There were no obvious side effects in the clinic.

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