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China Supply 9% Purity AZD 3759 CAS: 1626387-80-1 for Cancer Treatment

Item No.: 1626387-80-1
Model NO.: 1626387-80-1
Customized: Non-Customized
Suitable for: Elderly, Adult
Purity: >99%
Delivery Time: 4-7 Days
Transport Package: Foil Bag or Tin. &Well Disguised Package with Fast
Certification: GMP, ISO 9001
Appearance: White or off-White C
Description FAQ
Quick Details:

English name: AZD 3759
English Synonyms: AZD 3759; AZD3759; AZD-3759; (2R) -2,4-Dimethyl- 1-piperazinecarboxylic acid 4 - [(3-chloro-2- fluorophenyl) amino] HY-18750; azd3579;
CAS number: 1626387-80-1
Molecular formula: C22H23ClFN5O3
Molecular weight: 459.91


AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del, . AZD3759 inhibits EGFR phosphorylation with IC50 of 7.2 nM. AZD3759 showed an inhibitory effect on the proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and the EGFR mutant with IC50 of 7.7 nM and 7 nM, respectively, with no activity on the proliferation of H838 cells.
Phase 1 clinical trials of AZD3759 showed very good control activity of intracranial lesions, and the dose of this drug is recommended to be 200 mg or 300 mg twice daily. AZD3759 has no better control of extracranial lesions than the other EGFR-targeted agents, but shows greater control over intracranial lesions.


1.Non-small cell lung cancer is one of the major diseases that threaten human health. Even more serious is up to 50% of cancer patients with central nervous system metastasis in their lifetime, metastatic lung cancer is currently no cure. Recently, AstraZeneca's Chinese team led by Dr. Zhang Xiaolin successfully developed a new drug, AZD3759, to treat central nervous system metastases of lung cancer. Their early R & D results have been published in "Journal of Medicinal Chemistry".

2.In order to solve the challenging problem of blood-brain barrier, the author comprehensively optimizes structural parameters such as molecular size, polarity, rigidity and the like, and adjusts various biophysical and chemical properties such as basicity, water solubility, permeability and stability To the best condition to cross the blood-brain barrier. The fully optimized design has successfully brought AZD3759 to the same effective concentrations in different settings of the blood and central nervous system. In addition, the authors also published a preclinical in vitro and in vivo assessment of a subset of candidate compounds. Clinical studies of AZD3759 are underway.

How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

Payment and Shipping:

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Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!
Q1: Have your Product Quality been Approved by Third Party Lab?

A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China. So you will be assured with Good Quality if you choose us. 
Q2:How do you treat quality complaint?

A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC,TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: How to cooperate with us?

You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q4: Do you Accept Sample Order?

A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q5: Is there any discount?

A: Yes, for larger quantity, we always support with better price. 

Q6:Do you accept VISA business credit card ?

A:Sorry we don't accept VISA credit card,
we'd like to accept T/T , Moneygram ,Western Union.

Q7:How long does it take to the goods arrived ?

A:It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q8: Do you have any reshipment policy ?  

We have good after-sale service and re-shipment policy if the parcel  lose.
Our long association with  our clients has brought great benefits.
We always take the upmost care in the packaging of our products .
Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship.