Quick Details:
Other names: Qinghaosu, Arteannuin, Artemisinine
Botanical Source: Artemisia Annua L.
CAS No.: 63968-64-9
Plant Part Used: Leaf
Appearance: White needle crystal
Molecular Formula: C15H22O5
Molecular Weight: 282.33
Specification: Artemisinin 99% by HPLC
Artemisinin is Chinese first successfully developed by scientists, is the effective monomer separated from the treatment of malaria in China folk herbs of Artemisia annua, one of the major countries of the China raw materials of plant growth, development demand originated in 60s in Vietnam, has been on the chlorine Kui Plasmodium specific drug resistance, then not many soldiers died in the war, but died of malaria.
COA:
| Analysis Items | Specifications | Results | Methods used |
| Identification | Positive | Conforms | Chemical method/TLC/IR |
| Appearance | Colorless Crystal powder | Conforms | Visual test |
| Artemisinin, identification by IR Corresponds qualitatively to the Spectrum |
Corresponds qualitatively to the comparison | Conforms | / |
| Odor | Characteristic pleasant | Conforms | Organoleptic |
| Taste | Characteristic bitter | Conforms | Organoleptic |
| Assay on dry base | Artemisinin 99% min | 99.64% | By HPLC |
| Related substance | No more than 2.0% in each case | Conforms | HPLC |
| Total related substance | NMT 5.0% | Conforms | HPLC |
| Melting Point | 150-153ºC | 152.3-152.8ºC | CP2005 |
| Clarity to the solution 1 %( m/v) | Clear to slightly opalescent | Clear | / |
| Optical Rotation | +75°-- +78° | +75.8° | Optical Rotator |
| Moisture Content (5g) | NMT 0.5% | 0.19% | 1g / 80ºC |
| Residue on Ignition (2g) | NMT 0.1% | 0.03% | 1g/600-750ºC |
| Microbiological Data | Total Plate Count<1,000cfu/g | < 100 cfu/g | GB 4789.2 |
| Total Yeast & Mold<100cfu/g | < 30 cfu/g | GB 4789.15 | |
| E. Coli to be absent /g | Absent | GB 4789.3 | |
| Staphylococcus to be absent/g | Absent | GB 4789.10 | |
| Salmonella to be absent/g | Absent | GB 4789.4 |
Application:
Artemisia used as antimalarial drugs, clinical application proves that artemisinin and its derivatives on the effects between malaria and falciparum malaria, especially arteannuin (Artemtherin), which reduced cell clones of Plasmodium is stronger than other artemisinin drugs to kill. The utility model has the advantages of high efficiency, quick acting, low toxicity and no cross resistance with chloroquine, and can be used not only for treatment, but also for emergency treatment.
Applicable to all kinds of malaria, such as falciparum malaria, vivax malaria, chloroquine resistant malaria and cerebral malaria. Dangerous type. Most notably, dihydroartemisinin and its tablets. The efficacy of this medicine was 10 times higher than that of artemisinin, and the recurrence rate was only 1.95%. Therefore, it was named China's ten largest scientific and technological achievement in 1992. Artemisinin and its derivatives are not only an excellent antimalarial drug, but also potentially attractive in the treatment of other diseases.
The animal experiments showed that artemisinin in the treatment of Clonorchis sinensis, killing rate reached 100%; the treatment of animal schistosomiasis, pest control rate of 33.8-99.3%. The total effective rate of artemisinin in the treatment of disk lupus erythematosus is 90%. The curative effect of the treatment of dengue fever is obviously superior to that of morpholine, guanidine and other Western medicines. The study also showed that artemisinin can significantly improve lymphocyte conversion and enhance the immune function of antibodies. No product was found to have toxic effects on heart, liver and kidney. There were no obvious side effects in the clinic.
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